Sensibilidad y especificidad de la oximetría de pulso para detectarcardiopatías congénitas en recién nacidos / Sensitivity and specificity of pulse oximetry to detect congenital heart disease in newborns

Resumen Objetivo: Determinar la sensibilidad y especificidad de la oximetría de pulso, para detectar cardiopatías congénitas en recién nacidos sanos en alojamiento conjunto. Material y métodos: El estudio es de tipo multicéntrico, prospectivo y transversal, evaluando pacientes del Hospital Regional de Alta Especialidad "Bicentenario 2010" y el Hospital General "Dr. Norberto Treviño Zapata", en ciudad Victoria Tamaulipas, en un periodo que comprendió desde marzo del 2015 a marzo de 2017. Se determinó la oximetría de pulso a recién nacidos sanos antes del egreso hospitalario. Resultados: Se estudiaron 511 recién nacidos. La sensibilidad detectada fue del 88.89 % y una especificidad del 99.80%. Conclusión: Las cardiopatías congénitas en recién nacidos sanos en alojamiento conjunto, se pueden determinar mediante la oximetría de pulso pre y post-ductal.

Abstract Objective: To determine the sensitivity and specificity of pulse oximetry to detect congenital heart disease in healthy newborns in rooming-in. Material and methods: The study is multicenter, prospective and cross-sectional, evaluating patients from the Regional Hospital of High Specialty "Bicentenario 2010" and the General Hospital "Dr. Norberto Treviño Zapata", in the city of Victoria Tamaulipas, in a period from march 2015 to March 2017. Pulse oximetry was determined in healthy newborns before hospital discharge. Results: 511 newborns were studied. The sensitivity detected was 88.89% and a specificity of 99.80%. Conclusion: Congenital heart disease in healthy newborns in rooming-in can be determined by pre- and post-ductal pulse oximetry.

Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors / Soroprevalência da doença de Chagas em pacientes cardíacos do sul do Brasil e seu conhecimento sobre a parasitose e vetores

Abstract Chagas disease (CD) is considered a typical low-income population sickness of the developing countries in Latin America. Given the historical relevance of CD in individuals in southern Rio Grande do Sul (RS) State, Brazil, the aim of this study was to identify the knowledge of the CD and its vectors by cardiac patients, and the prevalence of anti-T cruzi antibodies in these individuals in Pelotas, city located in Rio Grande do Sul (RS) state, Brazil. The subjects with cardiac disease were submitted to a semi-structured questionnaire as well as two serological tests in order to detect anti-T. cruzi IgG antibodies. Of the individuals that born in municipalities showing the highest triatomine infestation rates in recent decades, 81.8% were able to recognize the vector insect (p = 0.0042; OR = 5.9), and 83.3% reported either themselves or someone in their families to have CD (p = 0.043, OR = 5.2). Of the 54 patients submitted to serological analysis, only 01 patient (1.9%) was positive for anti-T. cruzi antibodies, a 55 year old man from the rural area of Canguçu county. This study provides support for the evaluation to be extended to other cardiology centers, given the importance of Chagas disease in Brazil.

Resumo A doença de Chagas (DC) é considerada uma doença típica da população de baixa renda dos países em desenvolvimento da América Latina. Dada a relevância histórica da DC em indivíduos do sul do Estado do Rio Grande do Sul (RS), o objetivo deste estudo foi identificar o conhecimento da doença de Chagas (DC) e seus vetores em pacientes cardíacos, e a prevalência de anticorpos anti-T cruzi nesses indivíduos, em Pelotas, cidade localizada no Rio Grande do Sul (RS), Brasil. Os pacientes cardiopatas foram submetidos a um questionário semiestruturado, e também a dois testes sorológicos para detecção de anticorpos anti-T. cruzi IgG. Dos indivíduos que nasceram em municípios com as maiores taxas de infestação por triatomíneos nas últimas décadas, 81,8% foram capazes de reconhecer o inseto vetor (p = 0,0042; OR = 5,9), e 83,3% relataram que eles próprios ou alguém em suas famílias tem DC (p = 0,043, OR = 5,2). Dos 54 pacientes submetidos à análise sorológica, apenas 01 paciente (1,9%) foi positivo para anticorpos anti-T.cruzi, um homem de 55 anos da área rural do município de Canguçu. Este estudo fornece subsídios para que a avaliação seja estendida a outros centros de cardiologia, devido à importância da doença de Chagas no Brasil.

Nivel de estrés, calidad de sueño, ansiedad y depresión como factores de riesgo de cardiopatía isquémica en el Hospital Central Militar / Level of stress, sleep quality, anxiety and depression as risk factors of ischemic heart disease in military patients and lawyers of military central hospital

Resumen Introducción: La cardiopatía isquémica es la principal causa de mortalidad en México y el mundo, un reto importante para la salud pública dada su magnitud y el efecto negativo que ejerce sobre la salud de la población. Objetivos: Determinar si el nivel de estrés, calidad del sueño, ansiedad y depresión, son factores de riesgo para tener cardiopatía isquémica en pacientes militares y derechohabientes del Hospital Central Militar. Material y métodos: Se realizó un estudio observacional, analítico, casos tipo y controles, se determinó la fuerza de asociación entre el nivel de estrés, la calidad del sueño, la ansiedad y la depresión con la cardiopatía isquémica. El análisis se realizó mediante la prueba de X2 (chi cuadrado) y razón de momios ajustadas por sexo y edad. Resultados: Durante el estudio ingresaron 83 pacientes. La edad de los participantes fue de 62.95±9.13 años. El OR de la variable depresión fue de 4.176, IC (1.63-10.68), para la variable mala calidad de sueño: OR= 6.061, IC (2.278-16.124). Conclusiones: La depresión y la mala calidad del sueño son factores de riesgo para padecer cardiopatía isquémica en los pacientes militares y derechohabientes del Hospital Central Militar.

Abstract Introduction: Ischemic heart disease is the main cause of mortality in Mexico and the world, an important challenge for public health given its magnitude and the negative effect it has on the health of the population. Objectives: To determine if the level of stress, quality of sleep, anxiety and depression are risk factors for having ischemic heart disease in military patients and right holders of the Central Military Hospital. Material and methods: An observational, analytical, case-control study was conducted, the strength of association between stress level, sleep quality, anxiety and depression with ischemic heart disease was determined. The analysis was done by the X2 test (chi square) and odds ratio adjusted by sex and age. Results: During the study 83 patients entered. The age of the participants was 62.95 ± 9.13 years old. The OR of the depression variable was 4.176, CI (1.63-10.68), for the variable poor sleep quality: OR = 6.061, CI (2.278-16.124). Conclusions: Depression and poor sleep quality are risk factors for ischemic heart disease in military patients and right holders of the Central Military Hospital.

Efeito de diferentes modalidades de treinamento físico no consumo de oxigênio de pico em pacientes pós-infarto agudo do miocárdio: uma revisão sistemática e metanálise / Effect of different physical training modalities on peak oxygen consumptions in post-acute myocardial infarction patients: systematic review and meta-analysis

Resumo O treinamento físico é capaz de aumentar o consumo de oxigênio de pico em indivíduos que sofreram infarto agudo do miocárdio. No entanto, em relação à eficácia de diferentes tipos de intervenções ainda há uma lacuna na literatura. O objetivo do presente estudo foi avaliar os efeitos de diferentes modalidades de treinamento físico no consumo de oxigênio de pico de pacientes pós-infarto agudo do miocárdio. Foram utilizadas as seguintes bases de dados: PubMed (MEDLINE), Cochrane Library, Scopus e PEDro. Foram incluídos estudos que avaliassem exercícios aeróbicos, de força ou combinados. Seis estudos preencheram elegibilidade. O exercício aeróbico aumentou 6,07 mL.kg-1.min-1 quando comparado ao grupo controle (p = 0,013). Na comparação entre exercício combinado e grupo controle, foi observada uma diferença de 1,84 mL.kg-1.min-1, no entanto, sem significância (p = 0,312). Portanto, concluímos que o exercício aeróbico é a única modalidade que apresenta eficácia para aumentar o consumo de oxigênio de pico em comparação a um grupo controle.

Abstract Physical training can increase peak oxygen uptake (VO2peak) in people who have suffered acute myocardial infarction (AMI). However, there is still a gap in the literature in relation to the effectiveness of different types of interventions. Therefore, the aim of the present study was to evaluate the effects of different physical training modalities on VO2peak in post-AMI patients. The following databases were used: PubMed (MEDLINE), Cochrane Library, Scopus, and Pedro. Studies that evaluated aerobic exercise, strength exercise, or combined exercise were included. Six studies met eligibility criteria. Aerobic exercise increased VO2peak by 6.07 ml.kg-1.min-1 when compared to the control group (CG) (p = 0.013). The comparison between combined exercise and control group detected a difference of 1.84 ml.kg-1.min-1, but this was not significant (p = 0.312). We therefore conclude that aerobic exercise is the only modality that is effective for increasing VO2peak compared to a control group.

Atuação do psicólogo na unidade pediátrica em iminência de cirurgia cardíaca / Psychologists performance in the pediatric unit in imminence of cardiac surgery

O presente artigo, a partir do método de revisão bibliográfica da literatura, visou identificar e descrever a atuação do psicólogo hospitalar em manejar estratégias que possam preparar crianças com cardiopatias congênitas e seus familiares para o procedimento cirúrgico. A psicoprofilaxia realizada pelo profissional objetiva a preparação psicológica pré, peri, e pós-operatória e viabiliza meios de a criança enfrentar e dar novo significado ao processo a que é submetida. Ressalta-se que a eficácia do pós-operatório e, por conseguinte, a desospitalização exitosa, está diretamente relacionada com a preparação psicológica pré-cirúrgica realizada pelo psicólogo de forma tríade - o paciente infantil, seus familiares e a equipe de saúde. Este trabalho é de significativa importância para a compreensão do indivíduo em processo de adoecimento e resgate da subjetividade, bem como para possíveis contribuições para formação e atuação profissional hospitalar.

The present article, based on the method of bibliographic literature review, aimed to identify and describe the role of the hospital psychologist in managing strategies that can prepare children with congenital heart disease and their families for the surgical procedure. The psychoprophylaxis performed by the professional aims the pre, peri and postoperative psychological preparation and enables the means for the child to face and give new meaning to the process to which it is submitted. It is noteworthy that the effectiveness of postoperative period and, consequently, the successful deinstitutionalization, is directly related to the pre-surgical psychological preparation performed by the psychologist in a triad - the child patient, his family and the healthcare team. This work is of significant importance for the understanding of the individual in the process of becoming ill and rescuing subjectivity, as well as for possible contributions to hospital professional training and performance.

Estudio de la deformación miocárdica longitudinal en pacientes con cardiopatía isquémica / Study of longitudinal myocardial deformation in patients with ischemic cardiopathy

Resumen Introducción: Las enfermedades cardiovasculares constituyen la primera causa de muerte en Cuba y la mayoría de los países desarrollados. La ecocardiografía con speckle tracking bidimensional (ST 2D) es una técnica reciente en la evaluación de la función cardíaca. Objetivos: Determinar la relación entre la deformación miocárdica medida por ST 2D y el estado de la circulación coronaria en pacientes con cardiopatía isquémica, en el CIMEQ, durante un año. Material y método: Se realizó un estudio analítico y transversal con 55 pacientes con indicación de coronariografía sometidos a ecocardiograma bidimensional y estudio de ST 2D con medición de la deformación longitudinal (DLG). Se crearon dos grupos: enfermedad coronaria significativa (ECS = 32) y no significativa (ECNS = 23). Se utilizó SSPS para análisis de los resultados. Resultados: La edad promedio fue mayor en la ECS (55.6 ± 9.3 vs. 61.8 ± 8.8; p = 0.014). Predominaron los hombres con ECS (47.3%), los hipertensos (ECS = 90.6% y ENCS = 65.2%; p = 0.02) y los fumadores (ECS = 59.4% y ENCS = 17.4%; p = 0.002). El diagnóstico más frecuente fue la angina crónica estable (87%). En la ECS predominó la enfermedad de tres vasos (75%). La DLG fue menor en la ECS [(-20.0 ± 3.2 vs. -22.1 ± 3.6; p = 0.035); AUC = 0.458]. No hubo diferencias en la DLG según el número de vasos significativamente afectados. Conclusiones: Los resultados encontrados no justifican el empleo del ST 2D para diferenciar la ECS.

Abstract Introduction: Cardiovascular diseases are the leading cause of death in Cuba and most of the developed countries. Two-dimensional speckle tracking echocardiography (2D ST) is a recent technique in the evaluation of cardiac function. Objectives: To determine the relationship between myocardial deformation measured by 2D ST and coronary circulation in patients with ischemic heart disease, in the CIMEQ, for 1 year. Material and method: An analytical, cross-sectional study was carried out with 55 patients with an indication for coronary angiography who underwent 2D echocardiography and 2D ST study with longitudinal strain measurement (LSM). Two groups significant coronary disease (SCD = 32) and not significant (NSCD = 23) were created. SSPS was used to analyze the results. Results: The average age was higher in SCD (55.6 ± 9.3 vs. 61.8 ± 8.8, p = 0.014). Men with SCD (47.3%), hypertensive (SCD = 90.6% and NSCD = 65.2%, p = 0.02) and smokers (SCD = 59.4% and NSCD = 17.4%, p = 0.002) predominated. The most frequent diagnosis was chronic stable angina (87%). Three-vessel disease (75%) prevailed in SCD. The LMS was lower in SCD ([−20.0 ± 3.2 vs. −22.1 ± 3.6, p = 0.035]; AUC = 0.458). There were no differences in LSM according to the number of significantly diseased vessels. Conclusions: The results found do not justify the use of 2D ST to discriminate SCD.

Avaliação da deformação miocárdica pela ecocardiografia feature tracking em gatos com defeito perimembranoso do septo ventricular / Evaluation of myocardial deformation by the ecocardiography feature tracking in cats with perimembranosous defect of the septo ventricular

O desenvolvimento de novas ferramentas, como a ecocardiografia bidimensional feature tracking (2D-FTI), permite diagnosticar, de forma precoce, se há disfunção miocárdica em doenças cardíacas, inclusive as congênitas. O defeito septal ventricular (DSV) é a alteração congênita mais observada em felinos, no entanto pouco se sabe sobre a disfunção cardíaca nessa cardiopatia, especialmente em animais assintomáticos. O objetivo deste estudo foi avaliar, por meio do 2D-FTI, a deformação miocárdica ventricular esquerda pela mensuração dos índices ecocardiográficos strain (St) e strain rate (StR) radial, circunferencial e longitudinal, em gatos saudáveis e com DSV. Foram avaliados 12 gatos saudáveis e seis gatos com DSV para obtenção de St e StR em diversos segmentos miocárdicos. No sentido longitudinal, houve diferença estatística (P<0,05) para os segmentos septal basal, mediano e apical epicárdicos (P=0,0017; P<0,0001; P=0,0288), lateral mediano epicárdico (P=0,0327), septal mediano endocárdico (P=0,0035), lateral mediano endocárdico (P=0,0461), St epicárdico (P=0,0250) e St global (P=0,0382). Também houve diferença no segmento lateral mediano circunferencial endocárdico (P=0,0248), lateral mediano radial (St: P=0,0409; StR: P=0,0166) e posterior mediano radial (P=0,0369). O estudo evidenciou que, mesmo em animais assintomáticos com DSV, há redução na deformação miocárdica ventricular principalmente no sentido longitudinal, demonstrando maior vulnerabilidade dessas fibras.(AU)

The development of new tools, such as two-dimensional feature tracking (2D-FTI), allows early diagnosis of myocardial dysfunction in heart diseases including congenital heart disease. The ventricular septal defect (VSD) is the most frequently observed congenital abnormality in cats, however, little is known about cardiac dysfunction, especially in asymptomatic animals. The objective of this study was to evaluate the left ventricular myocardial deformation through 2D-FTI by the measurement of the radial, circumferential and longitudinal echocardiographic strain (St) and strain rate (StR) indices. Twelve healthy cats and six cats with VSD were evaluated to obtain St and StR in several myocardial segments. In the longitudinal direction, there was a statistical difference (P<0.05) for the epimyocardial basal septal, mid-septal, apical septal (P=0.0017; P<0.0001; P=0.0288), epimyocardial mid-lateral (P=0.0327), endomyocardial mid-septal (P=0.0035), endomyocardial mid-lateral (P=0.0461), St epimyocardial (P=0.0250) and St global (P=0.0382). There was also difference in the circumferential endomyocardial mid-lateral segment (P=0.0248), radial mid-lateral (St: P=0.0409; StR: P=0.0166) and radial mid-posterior (P=0.0369). The study showed that even in asymptomatic animals with VSD there is a reduction in ventricular myocardial deformation mainly in the longitudinal direction, demonstrating the fragility of these fibers.(AU)

Pregnancy in teenagers with heart disease / Embarazo en pacientes adolescentes con cardiopatía

Abstract The prevalence of pregnancy in adolescent women is high in Mexico and represents a public health problem. The pregnant teenager with heart disease has a high probability of complications during pregnancy and the delivery, which carries a risk of death of both the mother and the product. In many cases the pregnancy should have been avoided, planned or interrupted, however the majority at this age is vulnerable and although certain cases must be interrupted by their high risk of maternal-fetal death, prevention and legal aspects should be considered. In some cases the woman wants a pregnancy although her health condition does not allow it, but there are options of adoption or recourse to a surrogate belly. In response to this growing social problem, the National Cardiology Institute Ignacio Chávez and National Institute of Perinatology, with the coordination of Ministry of Health in Mexico, started a pregnancy prevention module within a clinic of follow-up of cardiopathy and pregnancy. This review raises the global problem in our country that occupies the first place in pregnancies in adolescents, with more than 400,000 pregnancies a year and the form of immediate response in a multidisciplinary way.

Resumen La prevalencia de embarazo en mujeres adolescentes es muy alta en México, y representa un problema de salud pública. La adolescente embarazada con cardiopatía tiene altas posibilidades de complicaciones durante el embarazo y su resolución, lo que pone en riesgo la vida tanto de la madre como del producto. En muchos casos el embarazo debió ser evitado, planeado o interrumpido, sin embargo la mayoría a esta edad es vulnerable y si bien ciertos casos deben ser interrumpidos por su alto riesgo de muerte materno-fetal, es fundamental considerar la prevención y los aspectos legales. En algunos casos la mujer desea un embarazo aunque su condición de salud no se lo permite, pero existen opciones de adopción o recurrir a un vientre subrogado. Atendiendo este problema social cada vez más creciente, el Instituto Nacional de Cardiología Ignacio Chávez, en coordinación con la Comisión Coordinadora de la Secretaría de Salud y el Instituto Nacional de Perinatología, echaron a andar un módulo de prevención de embarazo dentro de una clínica de seguimiento de cardiopatía y embarazo. Esta revisión plantea el problema global en nuestro país, que ocupa el primer lugar en embarazos en adolescentes, con más de 400 mil embarazos al año y la forma de dar respuesta inmediata de manera multidisciplinaria.

Long-term results of minimally invasive direct coronary artery bypass / 上海交通大学学报（医学版）

Objective • To summarize the experiences and follow-up results of minimally invasive direct coronary artery bypass (MIDCAB) for treating coronary atherosclerotic cardiopathy for 10 years and to evaluate the long-term effects of MIDCAB. Methods • The patients who underwent MIDCAB at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, from February 2009 to May 2019 were collected. According to whether the patients achieved complete revascularization (CR) or underwent hybrid coronary revascularization (HCR), the cases were divided into 3 groups: incomplete revascularization (IR) + optimal medical therapy (OMT) group, MIDCAB (CR) group and HCR (CR) group. The Kaplan-Meier (K-M) curve was used to analyze the long-term survival and the freedom from major adverse cardiac and cerebrovascular events (MACCE) of patients. Results • A total of 425 patients were enrolled in the study, with a median follow-up of 39.9 months (18.2-81.1 months). The hospital stay in the HCR (CR) group was significantly prolonged compared with the other two groups (P=0.000). The perioperative mortality (P=0.000), perioperative myocardial infarction (MI) rate (P=0.000), perioperative MACCE rate (P=0.000), cardiac troponin I (cTnI) levels in 48 h (P=0.011), long-term mortality (P=0.000), long-term MI rate (P=0.002), and long-term MACCE rate (P=0.005) in the IR + OMT group were significantly higher than those in the other two groups of patients who had CR. The overall 10-year survival rate and freedom from MACCE estimated by K-M curves were 80.9% (95%CI 73.1%-88.7%) and 70.5% (95%CI 62.1%-78.9%), respectively. The long-term survival (P=0.000) and freedom from MACCE (P=0.001) in IR+OMT group were significantly lower than those in the other two groups. Conclusion • MIDCAB has good long-term effects on patients with coronary atherosclerotic cardiopathy. Patients undergoing MIDCAB should complete CR, and IR can significantly affect the long-term prognosis of patients.

Predictors of Unfavourable Outcomes in Children and Adolescents Submitted to Surgical Mitral Valvuloplasty Secondary to Chronic Rheumatic Heart Disease / Preditores de Desfecho Desfavorável em Crianças e Adolescentes Submetidos à Valvoplastia Mitral Cirúrgica Secundária a Cardiopatia Reumática Crônica

Abstract Background: Mitral valve repair in paediatric patients with chronic rheumatic heart disease is superior to valve replacement and has been used with good results. Objective: To identify predictors of unfavourable outcomes in children and adolescents submitted to surgical mitral valvuloplasty secondary to rheumatic heart disease. Methods: Retrospective study of 54 patients under the age of 16 operated at a tertiary paediatric hospital between March 2011 and January 2017. The predictors of risk for unfavourable outcomes were: age, ejection fraction, degree of mitral insufficiency, degree of pulmonary hypertension, presence of tricuspid insufficiency, left chamber dilation, preoperative functional classification, duration of cardiopulmonary bypass, duration of anoxia, presence of atrial fibrillation, and duration of vasoactive drug use. The outcomes evaluated were: death, congestive heart failure, reoperation, residual mitral regurgitation, residual mitral stenosis, stroke, bleeding and valve replacement. For all analyzes a value of p < 0.05 was established as significant. Results: Of the patients evaluated, 29 (53.7%) were female, with an average of 10.5 ± 3.2 years. The functional classification of 13 patients (25%) was 4. There was no death in the sample studied. The average duration of extracorporeal circulation was 62.7±17.8 min, and anoxia 50 ± 15.7 min. The duration of use of vasoactive drug in the immediate postoperative period has an average of 1 day (interquartile interval 1-2 days). The logistic regression model was used to evaluate the predictive variables for each unfavourable outcome. The duration of use of vasoactive drug was the only independent predictor for the outcomes studied (p = 0.007). Residual mitral insufficiency was associated with reoperation (p = 0.044), whereas tricuspid insufficiency (p = 0.012) and pulmonary hypertension (p = 0.012) were associated with the presence of unfavourable outcomes. Conclusion: The duration of vasoactive drug use is an independent predictor for unfavourable outcomes in the immediate and late postoperative period, while residual mitral regurgitation was associated with reoperation, and both tricuspid regurgitation and pulmonary hypertension were associated with unfavourable outcomes.

Resumo Fundamento: A plastia da valva mitral, em pacientes pediátricos com cardiopatia reumática crônica, é superior à troca valvar e vem sendo utilizada com bons resultados. Objetivo: Identificar variáveis preditoras de desfecho desfavorável em crianças e adolescentes submetidos à valvoplastia mitral cirúrgica secundária à cardiopatia reumática. Métodos: Estudo retrospectivo em 54 pacientes menores de 16 anos, operados em um hospital pediátrico terciário entre março de 2011 e janeiro de 2017. As variáveis preditoras de risco para desfecho desfavorável foram: idade, fração de ejeção, grau de insuficiência mitral, grau de hipertensão pulmonar, presença de insuficiência tricúspide, dilatação de câmaras esquerdas, classe funcional no pré-operatório, tempo de circulação extracorpórea, tempo de anóxia, presença de fibrilação atrial e tempo de uso de droga vasoativa. Os desfechos avaliados foram: morte, insuficiência cardíaca congestiva, reoperação, insuficiência mitral residual, estenose mitral residual, acidente vascular cerebral, sangramento e troca valvar. Para todas as análises foi estabelecido valor de p < 0,05 como significante. Resultados: Dos pacientes avaliados, 29 (53,7%) eram do sexo feminino, com média de idade de 10,5 ± 3,2 anos. A classe funcional de 13 pacientes (25%) foi 4. Não houve morte na amostra estudada. O tempo médio de circulação extracorpórea foi de 62,7 ± 17,8 minutos e de anóxia 50 ± 15,7 minutos. O tempo de uso de droga vasoativa no pós-operatório imediato teve mediana de 1 dia (intervalo interquartil 1-2 dias). O modelo de regressão logística foi utilizado para avaliar as variáveis preditoras para o desfecho desfavorável. O tempo de uso de droga vasoativa foi o único preditor independente para os desfechos estudados (p = 0,007). A insuficiência mitral residual foi associada à reoperação (p = 0,044), enquanto a insuficiência tricúspide (p = 0,012) e a hipertensão pulmonar (p = 0,012) se associaram à presença de desfechos desfavoráveis. Conclusão: O tempo de uso de droga vasoativa é um preditor independente para desfechos desfavoráveis no pós-operatório imediato e tardio, enquanto insuficiência mitral residual se associou à reoperação e tanto a insuficiência tricúspide quanto a hipertensão pulmonar foram associadas a desfechos desfavoráveis.

Correlação entre os achados radiográficos e ecocardiográficos sugestivos de aumento cardíaco em cães: 104 casos / Correlation between radiographic and ecocardiographic findings suggestive of cardiomegaly in 104 dogs

Radiografias torácicas e ecocardiogramas de 104 caninos foram avaliados e correlacionados quanto ao aumento das câmaras cardíacas. Os achados radiográficos foram correlacionados estatisticamente a fim de se estabelecer a acurácia do exame radiográfico na detecção do aumento cardíaco em comparação ao ecocardiográfico - padrão-ouro não invasivo. A correlação entre os achados radiográficos indicativos de aumento cardíaco e os índices ecocardiográficos mostrou-se fraca, significativa somente para VHS versus relação átrio esquerdo/aorta (r=0,3136), eixo curto versus relação átrio esquerdo/aorta (r=0,3813) e eixo curto versus velocidade da onda E (r=0,2021). A acurácia da radiografia na determinação subjetiva de aumento das câmaras cardíacas foi razoável, variando entre 72,1% e 80,8%. Em contrapartida, o VHS apresentou baixa acurácia (50,9%) na detecção de cardiomegalia.(AU)

Thoracic radiographs and echocardiograms of 104 canines were evaluated and correlated regarding cardiac chambers enlargement. The radiographic findings were statistically correlated in order to establish the accuracy of the radiographic examination in the detection of cardiac enlargement in comparison with the echocardiogram - non-invasive gold standard. The correlation between the radiographic findings indicative of cardiac enlargement and echocardiographic indexes was weak, significant only for VHS versus left atrium to aorta ratio (r= 0.3136), short axis versus left atrium to aorta ratio (r= 0, 3813) and short axis versus E wave velocity (r= 0.2021). The radiographic accuracy in the subjective determination of cardiac chamber enlargement was reasonable, ranging from 72.1% to 80.8%. On the other hand, VHS presented low accuracy (50.9%) in the detection of cardiomegaly.(AU)

Morbilidad y mortalidad neonatal por cardiopatías congénitas / Neonatal javascript:void(0)morbidity and mortality by congenital cardiopathies

RESUMEN Introducción: Las cardiopatías congénitas inciden en 8 x 1 000 recién nacidos vivos en el mundo y en gran medida determinan su mortalidad. Objetivo: Precisar la morbilidad y mortalidad neonatal por cardiopatías congénitas. Métodos: Estudio descriptivo, longitudinal y prospectivo realizado en 97 recién nacidos con estas cardiopatías, diagnósticados en el Servicio de Neonatología del Hospital Dr. Agostinho Neto de Guantánamo durante los años 2015- 2017. Se consideró el análisis segmentario, probable mecanismos que la determinan y tipo de cardiopatía. Resultados: Se identificaron cardiopatías congénitas en el 12,9 por ciento de los recién nacidos; la letalidad fue de 1,0 por ciento. Lo más común fue que se identificaron modos y tipos de conexión auriculoventricular y ventriculoarterial fisiológicos. Las anomalías en la muerte celular (47,3 por ciento) fue el mecanismo genético y molecular más observado. La cardiopatía más frecuente fue la comunicación interventricular (63,9 por ciento). La mayoría de las cardiopatías se clasificaron como: aisladas (95,9 por ciento), de gravedad moderada (92,8 por ciento), acianóticas (93,8 por ciento), no se asociaran a síndromes o enfermedades genéticas (94,9 por ciento) pero sí a malformaciones extracardiacas (94,9 por ciento). Se manifestaron sobre todo por soplo cardiaco (85,6 por ciento). El diagnóstico de 70,1 por ciento de las cardiopatías se realizó en etapa prenatal. Conclusiones: Estas afecciones no constituyen un problema de salud en el servicio de este hospital, pero a pesar de que la mayoría de las cardiopatías congénitas se diagnostican en etapa prenatal, se requiere continuar laborando en función de potenciar más su diagnóstico en esta etapa(AU)

ABSTRACT Introduction: Neonatal congenital cardiopathies have a global incidence of 8 x 1000 live births and it greatly determines their mortality. Objective: To specify the neonatal morbidity and mortality by congenital cardiopathies. Method: Descriptive, longitudinal and prospective study of 97 newborns with these cardiopathies diagnosed in the Neonatolgy Service in ´Dr. Agostinho Neto Hospital, Guantánamo province from 2015 to 2017. It was considered: the segmental analysis, probable mechanisms that determine it and cardiopathy type. Results: Congenital cardiopathies were identified in 12.9 percent of the newborns; the lethality was of 1.0 percent. The most common aspect was the identification of ways and types of aurículo-ventricular and physiologic ventrículo-arterial connection. Anomalies in the cellular death (47.3 percent) were the most frequent genetic and molecular mechanism. The most frequent congenital heart disease was the interventricular communication (63.9 percent). Most of the cardiopathies were classified as: isolated (95.9 percent); of moderate graveness (92.8 percent); acyanotic (93.8 percent); not associated to syndromes or genetic diseases (94.9 percent) but yes to extracardiac malformations (94.9 percent); and they manifested mainly by heart murmur (85.6 percent ). The diagnosis of 70.1 percent of the cardiopathies was carried out in prenatal stage. Conclusions: Congenital cardiopathies don't constitute a health problem in the Neonatology service of the Hospital; but instead that these were mainly diagnosed in the prenatal stage, it is required to continue working in function of boosting their prenatal diagnosis(AU)

Anomalía de Ebstein en un paciente con síndrome de Down. Reporte de un caso / Ebstein's anomaly in a patient with Down syndrome. Case report

Resumen Paciente con síndrome de Down referido a nuestro departamento con cianosis y soplo cardíaco. Un ecocardiograma transtorácico mostró anomalía de Ebstein. Esta asociación es extremadamente rara. Se inició manejo médico ya que la lesión en la válvula tricúspide era leve. De acuerdo con nuestra revisión, se han descrito únicamente 12 casos en literatura médica.

Abstract An infant with Down's syndrome was referred to our department with cyanosis and heart murmur. A transthoracic echocardiogram demonstrated the presence of Ebstein's anomaly. This association is extremely unusual. Medical management was initiated since the tricuspid valve lesion was mild. Only twelve cases, to our knowledge, have been previously reported.

Cardiopatía congénita corregida en la mujer embarazada, experiencia en un hospital de tercer nivel / Correction congenital heart disease in pregnancy patients. Experience in a third level hospital

Resumen OBJETIVO: Describir los desenlaces cardiovasculares, obstétricos y perinatales durante el embarazo y puerperio de pacientes con cardiopatía congénita corregida. MATERIALES Y MÉTODOS: Estudio de cohorte simple, retrospectivo, descriptivo y transversal efectuado en pacientes embarazadas con cardiopatía congénita corregida, atendidas en el Instituto Nacional de Perinatología, entre enero de 2015 y febrero de 2017. Del expediente clínico se obtuvieron los datos demográficos, además de evaluar el riesgo de cardiopatía según la clasificación de la OMS, las comorbilidades y desenlaces obstétricos y perinatales. El análisis estadístico se realizó con el programa SPSS, versión 20. RESULTADOS: Se registraron 24 pacientes con cardiopatía congénita, principalmente comunicación interauricular e interventricular y coartación aórtica. La edad promedio fue de 24.6 años. En cuanto a la clasificación de riesgo de la OMS se encontraron 7 de 24 en OMS I, 8 de 24 en OMS II, 7 de 24 en OMS II-III y 2 de 24 en OMS III. Se observó que 13 de 24 pacientes tenían parche de pericardio bovino, 3 de 24 stent y 4 de 24 válvulas; 1 de 24 tuvo aborto espontáneo, 1 de 24 nacimiento pretérmino y 22 de 24 embarazo de término. El promedio de edad gestacional fue de 38.5 semanas y Apgar a los cinco minutos de 9. Ningún recién nacido ingresó a la unidad de cuidados intensivos, ni se registraron muertes maternas. CONCLUSIONES: El riesgo de alteraciones cardiovasculares durante el embarazo depende de la identificación de la cardiopatía específica y el estado clínico de la paciente. Es importante la asesoría individual, por un equipo multidisciplinario y en un centro especializado desde la etapa inicial del embarazo.

Abstract OBJECTIVE: To describe the cardiovascular, obstetric and perinatal outcomes during pregnancy and the puerperium of patients with corrected congenital heart disease; treated at the Instituto Nacional de Perinatología. MATERIALS AND METHODS: Simple, retrospective, descriptive and cross-sectional cohort study of pregnant patients with corrected congenital heart disease treated at the Instituto Nacional de Perinatología of January 2015 at February 2017. The cardiovascular risk according to WHO, comorbidities, obstetric outcomes and perinatal. Demographic data, WHO risk, comorbidities, obstetric outcomes and perinatal. The statistical analysis was carried out with the SPSS program in its version 20. RESULTS: We included 24 patients with congenital heart disease, the most frequent being interatrial and interventricular communication, aortic coarctation; average age of 24.6 years, the WHO risk distribution: 7/24 OMS I, 8/24 OMS II, 7/24 OMS II-III y 2/24 OMS III; 13/24 had a bovine pericardium patch, 3/24 stent, 4/24 valves;1/24 presented spontaneous abortion, 1/24 preterm birth, 22/24 achieved full-term gestation, average gestational age at the resolution of 38.5 SDG, Apgar at 5 minutes of 9, no newborn required admission to NICU, no maternal death occurred. CONCLUSION: The risk of pregnancy depends on the heart disease and clinical condition of the patient. Individual counseling is important, by a multidisciplinary team and in a specialized center from the early stage of pregnancy.

Efeito agudo e crônico do treinamento aquático nas variáveis hemodinâmicas de pacientes cardiopatas: uma análise retrospectiva / Acute and chronic effects of aquatic training on hemodynamic variables of cardiac patients: a retrospective analysis

Introdução: A Insuficiência Cardíaca é uma patologia causada por várias desordens estruturais e funcionais que resultam na intolerância ao exercício, porém o treinamento aquático tem-se mostrado um importante método para a reabilitação de cardiopatas. Objetivo: Avaliar o comportamento hemodinâmico agudo e crônico de pacientes cardiopatas submetidos a um protocolo de treinamento aquático. Material e métodos: A amostra foi constituída por seis indivíduos com diagnóstico de cardiopatia, com idade de 68,3 ± 8,9 anos. Foram levantados dados dos prontuários referentes a características da amostra, pressão arterial sistólica (PAS), pressão arterial diastólica (PAD), frequência cardíaca (FC) e duplo produto (DP) pré e pós-sessão de treinamento aquático com frequência de duas vezes semanais, durante noventa dias. Resultados: Quanto ao efeito agudo, observou-se um aumento da FC no 2º (p=0,001) no 3º mês (p=0,033) e um aumento do DP no 2º mês (p=0,033) e no 3º mês (p=0,028) no pós-exercício em relação ao pré-exercício. Quanto ao efeito crônico, observou-se aumento na FC entre o segundo e o terceiro mês (p=0,044). Conclusão: O treinamento aquático foi capaz de aumentar aguda e cronicamente a FC e o DP em pacientes cardiopatas, sem alterações na pressão arterial.

Introduction: The cardiac insufficiency is a pathology caused by many structural and functional disorders which result in exercise intolerance. However, the aquatic training has been shown as an important method used in rehabilitation programs for cardiac patients. Objective: To evaluate the acute and chronic hemodynamic behavior of cardiac patients performing an aquatic training protocol. Methods: The six investigated individuals were 68.3 ± 8.9 years old, all of them with cardiopathy diagnostic. The systolic and diastolic blood pressure and the heart rate data, before and after exercise, were taken from medical records. The training sessions were conducted twice a week, during 90 days. Results: The acute effect of exercise increased the heart rate during the second (p=0.001) and the third (p=0.033) months, and also increased the double-product during the same periods (p=0.033 and p=0.028, respectively), comparing data before and after exercise. The chronic effect was observed by the increase of the heart rate in the third month compared to the second (p=0.044). Conclusion: The acute and chronic effect of the aquatic training increased the heart rate and the double-product of cardiac patients without blood pressure variations.

Síndrome de Adams-Oliver en dos casos clínicos / Adams-Oliver Syndrom in two clinical cases

Introducción: El síndrome de Adams-Oliver es una enfermedad heterogénea, caracterizada por aplasia cutis congénita y defecto transverso terminal de extremidades, con un amplio espectro fenotípico de malformaciones asociadas. Se han descrito diferentes modos de herencia en esta enfermedad. En el contexto cubano no se ha presentado ni publicado hasta el momento, casos de pacientes afectados por este síndrome Objetivo: Aportar evidencia que demuestra la presentación de casos con síndrome de Adams-Oliver. Presentación de casos: Se exponen dos casos de pacientes neonatales con síndrome de Adams-Oliver desde el punto de vista clínico, ambos de presentación esporádica. Además de la aplasia cutis congénita y el defecto transverso terminal de extremidades, uno de los pacientes exhibía cutis marmorata telangiectásica congénita y una anomalía de Ebstein. Conclusiones: Se exponen dos neonatos con síndrome de Adams-Oliver, ambos de presentación esporádica y uno de estos con una cardiopatía congénita (anomalía de Ebstein) no informada hasta ahora en la literatura(AU)

Introduction: The Adams-Oliver syndrome is a heterogenic disease characterized by aplasia cutis congenita and terminal transverse limb defects, with a wide phenotypic spectrum of associated malformations. Different kinds of inheritance of this disease have been described. In Cuba, any cases of patients suffering this syndrome have not been presented or published so far. Objective: To provide evidence demonstrating the presentation of cases with Adams-Oliver syndrome. Cases report: Two cases of neonatal patients with Adams-Oliver syndrome are presented from the clinical point of view, both of which are sporadic. In addition to the aplasia cutis congenita and the terminal transverse defect of the limbs, one of the patients presented congenital cutis marmorata telangiectatic and Ebstein anomaly. Conclusions: Two newborns cases with Adams-Oliver syndrome, both of sporadic presentation and one of these with a congenital heart disease (Ebstein anomaly) not previously reported in the literature are presented(AU)

Cardiopatías congénitas en edad pediátrica, aspectos clínicos y epidemiológicos / Congenital heart disease in pediatric age, clinical and epidemiological aspects

RESUMEN Las malformaciones cardíacas congénitas constituyen un perfil de mortalidad que se planifica modificar de acuerdo con los objetivos, propósitos y directrices declarados por el Ministerio de Salud Pública. Para los pediatras es una preocupación el control de la morbilidad y mortalidad por esta causa, así como las acciones que contribuyen a facilitar las prioridades de salud de acuerdo a la evaluación de los resultados alcanzados en los programas y servicios implementados en relación con estas afecciones, por lo que el estudio de las cardiopatías congénitas deviene en una prioridad. Ante esta situación se decidió describir las características generales de esta afección mediante una revisión bibliográfica donde se expongan sus principales manifestaciones clínicas, factores etiológicos, clasificación, fisiopatología, aspectos demográficos, diagnóstico y tratamiento. Para ello se realizó una revisión bibliográfica de los trabajos más relevantes publicados a escala nacional e internacional y con ello contribuir en el proceso de educación médica continuada que se está ejecutando en la Universidad Médica y en todo el sector salud en nuestra provincia. Adicionalmente, el trabajo pudiera facilitar la creación de planes de acción que permitan en el futuro disminuir la prevalencia de cardiopatías congénitas en la provincia (AU).

ABSTRACT Congenital cardiac malformations constitute a mortality profile that is planned to be modified in accordance with the objectives, purposes and guidelines declared by the Ministry of Public Health. For pediatricians, it is a concern to control morbidity and mortality for this cause, and actions that contribute to facilitate health priorities with the evaluation of the results achieved in the programs and services implemented in relation to these conditions, the study of congenital heart disease becomes a priority. In view of this situation, the general objective of this condition is to describe the general characteristics of this condition by means of a bibliographical review that brings together its main clinical manifestations, etiological factors, classification, pathophysiology, demographic aspects, diagnosis and treatment. This will raise the level of knowledge about these diseases to identify risk factors preconceptionally and establish action plans that will in the future reduce the prevalence of congenital heart disease in the province (AU).

Factores de riesgo de cardiopatía isquémica en área intensiva municipal. Pedro Betancourt. 2013- 2014 / Risk factors of ischemic cardiopathy in the municipal intensive care area. Pedro Betancourt. 2013-2014

Introducción: la cardiopatía isquémica es un problema de salud que cobra un gran número de vidas y es causa de invalidez en la población mundial. Constituyó en el 2013, la primera causa de muerte en el mundo, en Cuba y en la provincia de Matanzas. Objetivo: cuantificar la presencia de factores de riesgo de cardiopatía isquémica en el AIM del Policlínico Docente Cesáreo Sánchez, en Pedro Betancourt entre los meses de diciembre 2013 a Mayo del 2014. Materiales y Métodos: se realizó un estudio observacional, descriptivo, transversal de 59 pacientes que ingresaron con este diagnóstico entre los meses de diciembre 2013 a Mayo 2014. Se recogieron variables como la edad, sexo, factores de riesgo, formas clínicas de presentación, complicaciones presentadas durante el ingreso y presencia del síndrome metabólico. Resultado: hubo un predominio del sexo masculino y del grupo de edad de 65 y más. La hipertensión arterial y el sedentarismo fueron los factores de riesgo más sobresalientes, así como la angina estable y las arritmias cardíacas como la forma clínica y complicación más frecuente respectivamente. La presencia del síndrome metabólico caracterizó a los pacientes estudiados. Conclusiones: la detección y control oportuno de los factores de riesgo de la cardiopatía isquémica continuara siendo la piedra angular de cualquier estrategia preventiva esencial (AU).

Introduction: the ischemic cardiopathy or ischemic cardiovascular disease is a health problem claiming a great number of lives, being a cause of disability in the world population. In 2013 it was the first cause of death worldwide, in Cuba and in the province of Matanzas. Objective: to quantify the presence of the ischemic cardiopathy risk factors in the municipal intensive area (AIM as abbreviation in Spanish) of the Teaching Policlinic Cesareo Sanchez, in Pedro Betancourt, from December 2013 to May 2014. Materials and methods: a cross-sectional, descriptive, observational study was carried out in 59 patients who entered the area with this diagnosis from December 2013 to May 2014. The collected variables were age, sex, risk factors, clinical forms of presentation, complications during staying, and presence of the metabolic syndrome. Results: the results showed the predominance of the male sex and the age group of 65 years and more. Arterial hypertension and sedentary lifestyle were the most outstanding risk factors, and the stable angina and heart arrhythmias were the most frequent clinical form and complication, respectively. The presence of metabolic syndrome characterized the studied patients. Conclusions: the timely detection and control of the ischemic cardiopathy risk factors is still going to be the cornerstone of any essential preventive strategy (AU).

Effects of extract from fermented buckwheat flower and leaf(EFBFL)on myocardial injury in type 2 diabetic db/db mice / 中国药理学通报

Aim To discuss the effectsof extract from fermented buckwheat flower and leaf(EFBFL) on myocardial injury in spontaneously obese type Ⅱ diabetic db/db mice and its mechanism.Methods 9-week-old male db/db mice were randomly divided into high level EFBFL dose group(EFBFL-H, 0.1 g·kg-1), low level EFBFL dose group(EFBFL-L, 0.05 g·kg-1),metformin hydrochloridecontrol group, model control group, and normal control group, with 10 mice in each group.All groups were treated with 8 wks of drugs by gastric perfusion.The random blood glucose(RBG) was tested respectively at the end of 2nd, 4th, 6th, and 8th wk.Finally, the levels of creatine kinase(CK) creatine kinase MB(CK-MB), andadvanced glycosylation endproducts(AGEs) were detected after 8 wks.The morphological changes of myocardium were observed under light microscope by HE staining, and the ultrastructure of myocardium was observed under electron microscope.Immunohistochemical method and Western blot were used to detect myocardial tissue glucose transporter-4(Glut-4).Results EFBFLcould repress patho-proceeding of myocardial fibrosis efficiently, and significantly decrease the level of blood glucose, CK,CK-MB, and AGEs in db/db mice.Meanwhile, it could increase the expression of Glut-4 in myocardial tissues of mice.Conclusions EFBFL can prevent myocardial injury in spontaneously obese type Ⅱ diabetic db/db mice.The possible mechanism may be related to lowering the level of blood glucose and serum AGEs and up-regulating Glut4of cardiac muscle.